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KMID : 0604520160420040433
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Journal of the Society of Cosmetic Scientists of Korea
2016 Volume.42 No. 4 p.433 ~ p.440
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Self-assembly of Retinoic Acid-conjugated Poly(Amino Acid)’s Derivative
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Han Sa-Ra
Lee Hyeong-Yeong
Kim Hee-Jin
Cho Yoon-Na
Lee Seung-Jun
Zhoh Choon-Koo
Jeong Jae-Hyun
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Abstract
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In this study, a poly (amino acid)s derivative grafted with retinoic acids, which could form self-assemblies in an aqueous solution, was successfully synthesized. The synthesized amphiphilic poly (amino acid)s were controlled with 5, 10, 30 mol% substitution of retinoic acid. Then, the amphiphilic poly (amino acid)s were self-assembled by inter/intra molecular stacking of retinoic acids in an aqueous solution. Also, the increasing the degree of substitution (DS) of retinoic acids decreased the size of self-assembled nanoparticles and induced structural transition to bilayer structure from spherical structure. The retinol was stably encapsulated into a core of self-assembled nanoparticle with 10 mol% of DS. This strategy to prepare the self-assemblies of amphiphilic polyaspartamide will serve to improve the efficiency of targeted delivery for a functional cosmetic with various biological modalities.
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KEYWORD
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polyaspartamide, retinol, self-assembly, degree of substitution
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